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Description

Phase transfer catalysis is used to facilitate a reaction where the reactants are in two separate immiscible phases. In the ideal reaction scheme, we aim to synthesize a 3-bromomethyl phenol in the lab before reacting it with the nitrogen on a cinchonine backbone. This catalyst will activate the electrophile and the nucleophile, creating a new chiral center. After this is completed, we will work on synthesizing similar phenol groups to use in the discovery of new enantioselective reactions. Once purified and synthesized, we aim to screen this catalyst and any of the others we create for use in applicable reactions.

Publication Date

4-30-2026

Keywords

Organic synthesis, catalysis

Synthesis of Novel Enantioselective Phase-Transfer Catalysts

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