Scale-Up of Microwave-Promoted Reactions to the Multigram Level Using a Sealed-Vessel Microwave Apparatus
Article - Merrimack Access Only
Organic Process Research & Development
American Chemical Society
A range of synthetic transformations have been scaled up successfully using a sealed-vessel multimode microwave unit. These include metal-catalyzed couplings, synthesis of heterocycles, reactions under an atmosphere of reactive gas and two-step one-pot procedures. Also, observations have been made along the way that are of use to chemists addressing scale-up of microwave-promoted reactions.
Bowman, M. D.,
Schmink, J. R.,
McGowan, C. B.,
Kormos, C. M.,
Leadbeater, N. E.
(2008). Scale-Up of Microwave-Promoted Reactions to the Multigram Level Using a Sealed-Vessel Microwave Apparatus. Organic Process Research & Development, 12(6), 1078-1088.
Available at: http://scholarworks.merrimack.edu/chm_facpub/21